Main Difference. Abbreviation and acronym are two ways of shortening a long group of words or a large word. Acronyms are generally written in capital letters; for example, AIDS – Acquired Immuno-Deficiency Syndrome, NATO – North Atlantic Treaty Organization, OPEC -Organization of Petroleum Exporting Countries.
FWIW, Merriam-Webster is not one of them: I would dispute that an acronym is the same as an initialism, and that e.g.

Although abbreviations and acronyms appear to be similar, they have few differences. Filed Under: Words Tagged With: Abbreviations, Abbreviations and acronyms, Abbreviations vs acronyms, Acronym and Abbreviation, acronyms, breves, shortened word of phrase. (adsbygoogle = window.adsbygoogle || []).push({}); Copyright © 2010-2018 Difference Between. Acronym. Difference Between Mentoring and Coaching, Difference Between May and Might in English Grammar, Side by Side Comparison – Acronym vs Abbreviation in Tabular Form, Difference Between Coronavirus and Cold Symptoms, Difference Between Coronavirus and Influenza, Difference Between Coronavirus and Covid 19, Difference Between Linear and Rotary Molecular Motors, Difference Between Egyptian Cotton and Regular Cotton, Difference Between Insecticides and Pesticides, Difference Between Primary and Secondary Mycelium, Difference Between Stannic and Stannous Chloride, Difference Between Mycorrhiza and Coralloid Roots, Difference Between Red Oxide and Zinc Chromate Primer, Difference Between Golden Rice and Normal Rice. Examples of acronyms: CEO (cheif executive officer), AIDS (Acquired immune deficiency syndrome), FAQ (frequently asked questions), CD-ROM (compact-disk read-only memory), (Notice that they may be pronounced as words themselves or spelt out depending on the case.).…,, Feature Preview: New Review Suspensions Mod UX. What are the differences between abbreviation, contraction and acronym? :).

@CharlesRoper I don't have any statistics, but a number of years ago I did some searches on Google books for "is an acronym" and sifted through pages and pages of results, looking at the string that preceded the match, and found that about 40% of results were strings that would be pronounced by naming the letters rather than "as a word".
There is a great deal of overlap between abbreviations and acronyms. for example, prof. for professor, and dr. for doctor. Some examples are Mr. for mister, govt. Dec. for December, Mr for Mister etc. Most dictionaries (ODO, CDO, AHDEL, Collins, Farlex ...) include the 'pronounced as [if it were actually] a word' restriction in the first sense defined. Can a single card have multiple activations on a stack?

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